Advances in Genome Biology, Vol. 4: Genetics of Sex Determination

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Please take this quick survey to tell us about what happens after you publish a paper. Chromosome Research. Several genes located within or proximal to the human PAR in Xp22 have homologues on the Y chromosome and escape, or partly escape, inactivation. We demonstrate that the genes residing proximal to the PAR have a highly conserved order on the higher primate X chromosomes but show considerable rearrangements on the Y chromosomes of hominoids.

These rearrangements cannot be traced back to a simple model involving only a single or a few evolutionary events. The linear instability of the Y chromosomes gives some insight into the evolutionary isolation of large parts of the Y chromosomes and thus might reflect the isolated evolutionary history of the primate species over millions of years. Unable to display preview. Download preview PDF. Skip to main content. Advertisement Hide. Comparative mapping of Xp22 genes in hominoids — evolutionary linear instability of their Y homologues.

Authors Authors and affiliations B. Taylor K. Schiebel G. Meroni K. Tsioupra J. Pasantes W. Rietschel R. Toder U. Willmann S. Zeitler P. Yen A. Ballabio G. Rappold W. This is a preview of subscription content, log in to check access. Nucleic Acids Res 17 : — PubMed Google Scholar.

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In: Wachtel SS, ed. Molecular Genetics of Sex Determination. London: Academic Press, pp — Google Scholar. Hum Mol Genet 3 : — Nature Genet 2 : — Trends Genet 5 : — Cell 63 : — Cell 81 : 15— Fraser N. Ballabio A, Zollo M, Persico G, Craig IW Identification of incomplete coding sequences for steroid sulphatase on the human Y chromosome: evidence for an ancestral pseudoautosomal gene?

Development Suppl. Chrom Res 5 : 23— BioEssays 17 : — Mitelman F, ed. Jauch A, Wienberg J, Stanyon R et al Reconstruction of genomic rearrangements in great apes and gibbons by chromosome painting. Hum Mol Genet 4 : — Hum Mol Genet 5 : — Hum Genet 82 : 81— CrossRef Google Scholar.

The ongoing revision of the data available at NCBI and other online research databases provides an authentic opportunity to reinforce to students who are really, scientists-in-training the idea that scientific knowledge is always open to revision as new information comes to light, better tools are created for looking at data or measuring phenomena, and understanding is advanced.

Exploring the relationship of human autosomes and sex chromosomes. Supplementary File S5: Homologous chromosome-Investigation 3:Sex-reversal and other deleterious mutations of theSRY gene in humans, sex-specific diseases. Supplementary File S6: Homologous chromosome-Optional Extension 1: Sex determination varies among vertebrates Possible extension related to the diversity of mechanisms of sex determination employed in major clades of vertebrates.

Provides questions and answers for practice interpreting phylogenetic trees. Possible extension related to the definition of biological sex and social definitions of gender in the context of gender testing for athletic competition and current recommendations of the International Olympic Committee regarding gender testing and athlete eligibility. Provides answers to the questions embedded in each Investigation as well as the Pre- Investigation Questions. Provides basic definitions to the terms used in the lesson; may be useful for instructors to review in preparation for the lesson, or to provide to students as an additional resource.

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You are here Home Courses Homologous chromosomes? Exploring human sex chromosomes, sex determination and sex reversal using bioinformatics approaches Homologous chromosomes?

Exploring human sex chromosomes, sex determination and sex reversal using bioinformatics approaches Lesson. Kelsey Metzger, University of Minnesota, Rochester. Science Process Skills. Introductory Biology.

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Citation Metzger, K. Transmission - Patterns of Inheritance : How can one deduce information about genes, alleles, and gene functions from analysis of genetic crosses and patterns of inheritance? Genetic variation : How do different types of mutations affect genes and the corresponding mRNAs and proteins? Asking a question : Asking a question.

Lesson Learning Goals Students will understand the genetic basis of human chromosomal sex determination and be able to use bioinformatics evidence e. Lesson Learning Objectives Students successfully completing this lesson will: Practice navigating an online bioinformatics resource and identify evidence relevant to solving investigation questions Contrast the array of genes expected on homologous autosomal chromosomes pairs with the array of genes expected on sex chromosome pairs Use bioinformatics evidence to defend the definition of homologous chromosomes Define chromosomal sex and defend the definition using experimental data Investigate the genetic basis of human chromosomal sex determination Identify at least two genetic mutations can lead to sex reversal.

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Assessment Instructors can use various forms of formative and summative assessment relevant to this lesson. Article Context Course Level:. Class Size:. Bloom's Cognitive Level:. Key Scientific Process Skills:.

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